Our Science

Lipid Rafts
in Cancer

Lipid rafts - specialized microdomains within the plasma membrane - play a significant role in cancers by facilitating processes like cell signaling, proliferation, survival, invasion, metastasis, and drug resistance. The enriched presence of lipid rafts allow cancer cells to thrive by allowing the efficient uptake of lipids out of the microenvironment and providing more efficient cell signaling by coalescing necessary signal proteins in specific areas.

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PDC Platform &
Mechanism of Action

Our PDCs can target and gain access to cancer cells through attachment to lipid rafts. Learn more about PDCs.

Phospholipid Ether (PLE)

Cancer-Targeting Vehicle

LINKER

Versatile Chemistry

DRUG (Radioisotope, Small Molecule, Biologic)

Payload

Phospholipid Drug Conjugate (PDC)

Cancer-Targeted Payload

Lipid Rafts in Tumor Types

Lipid rafts are present in higher levels in cancer cells and play a critical role in cancer development and progression. Learn more about their role in specific tumor types:

Waldenström macroglobulinemia (WM)

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Multiple Myeloma (MM)

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Indolent Non-Hodgkin Lymphoma (iNHL)

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High-Grade Glioma (HGG)

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Pancreatic Cancer (PC)

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Triple-negative Breast Cancer (TNBC)

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Head and Neck Cancer (HNC)

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