Form: EFFECT

Notice of Effectiveness

May 3, 2010

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Notice of Effectiveness
Effectiveness Date: May 3, 2010
Accession Number: 0001144204-10-020124
Submission Type: POS AM
CIK: 0001279704
Company Name: NOVELOS THERAPEUTICS, INC.
File Number: 333-161922