Form: EFFECT

Notice of Effectiveness

April 28, 2008

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Notice of Effectiveness
Effectiveness Date: April 28, 2008
Accession Number: 0001144204-08-022683
Submission Type: POS AM
CIK: 0001279704
Company Name: NOVELOS THERAPEUTICS, INC.
File Number: 333-143263