Form: EFFECT

Notice of Effectiveness

March 28, 2007

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Notice of Effectiveness
Effectiveness Date: March 28, 2007
Accession Number: 0001144204-07-013898
Submission Type: POS AM
CIK: 0001279704
Company Name: NOVELOS THERAPEUTICS, INC.
File Number: 333-133043