Form: EFFECT

Notice of Effectiveness

November 21, 2006

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Notice of Effectiveness
Effectiveness Date: November 21, 2006
Accession Number: 0001144204-06-048672
Submission Type: POS AM
CIK: 0001279704
Company Name: NOVELOS THERAPEUTICS, INC.
File Number: 333-133043